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pentobarbital will lower the level or result of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will minimize the level or outcome of oliceridine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. If coadministration that has a CYP3A4 inducer is critical, consider escal